Carbapenemases in Gram-Negative Bacteria: Laboratory Detection and Clinical Significance

Carbapenemases in Gram-Negative Bacteria: Laboratory Detection and Clinical Significance

1 Clinical Department for Clinical and Molecular Microbiology, University Hospital Center Zagreb, 10000 Zagreb, Croatia 2 Department of Microbiology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia 3 Department of Microbiology, University Hospital Center Split, 21000 Split, Croatia 4Cantonal Public Health Institute Zenica, 72000 Zenica, Bosnia and Herzegovina 5 Department for Sa...

laboratory detection of carbapenemases in gram-negative bacteria

the nosocomial infections, caused by multi-drug resistant bacteria, are the most important cause of mortality throughout the world. one important mechanism against beta-lactam antibiotics is the production of beta-lactamases. enterobacteriaceae and non-fermentative bacteria, like pseudomonas aeruginosa and acinetobacter baumannnii may produce these enzymes. currently, there is no vaccine to pre...

Simple screening tests for detection of carbapenemases in clinical isolates of nonfermentative Gram-negative bacteria.

BACKGROUND & OBJECTIVE The production of carbapenemases is an important mechanism responsible for the carbapenem resistance. A simple and inexpensive testing method for screening of carbapenemase producers is essential. A prospective study was undertaken to detect metallo-beta-lactamases (MBLs) and AmpC beta-lactamases in nonfermentative Gram negative bacteria and to evaluate the various method...

Cell Envelope Structure and Functions in Gram-negative Bacteria

Dissemination of carbapenemases producing Gram negative bacteria in the Middle East.

The emergence and spread of carbapenemase-producing bacteria, that hydolyze most β-lactams, including carbapenems, are a major concern of public health system worldwide, particularly in the Middle East area. Since the plasmids harboring resistance genes could be spread across other bacterial populations, detection of carbapenemase-producing organisms has become more problematic. These organisms...